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Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management is a modern, expertly crafted and clinically focused guide to the diagnosis, management and best-practice care of patients suffering from pancreatic cancer, cystic neoplasms and endocrine tumours. Packed with outstanding figures and with reference to the leading society guidelines, its main focus is on the many endoscopic and radiologic diagnostic techniques, medical and surgical management of both full-blown cancer and other tumors, and the risks of each form of treatment. Also covered in detail are issues of tumor recurrence and long-term outcome of treatment. Brought to you by highly skilled national and international leaders in the specialty and an experienced editor team, this is an invaluable guide to practicing gastroenterologists and surgeons in the hospital and clinical environment, as well as oncologists and endocrinologists managing patients with pancreatic tumorous lesions.

Improve your dermatological diagnostic accuracy. The most efficient method in the diagnosis of skin diseases is the combined validation of clinical and histopathological features. The results of biopsy investigation in isolation don’t always yield answers. But when considered together, the clinical pattern and the histopathology, then diagnosis can become clearer. In this process the diagnostic impact of histopathology may be decisive or just confirmative to the clinical differential diagnosis. The structure of the book follows a basic approach to morphology, which is overall orientation at scanning magnification first, then identifying a prototypic pattern, and finally finding the essential diagnostic clue(s) under high power magnification. Dermatopathology: Practical Differential Diagnosis by Clinicopathologic Pattern provides top quality images to correlate clinical presentations with histopathologic features. Annotated images highlight subtle indications that can clinch the diagnosis. Concise, bullet-pointed text provides further context. Written by internationally renowned authors, the book is ideal for anyone involved in the diagnosis of skin disease.

This book is a practical and easily readable guide for neurologists, obstetricians, and primary care doctors treating female patients with neurological illness in their reproductive years. Offers wide ranging coverage, including family planning and lactation Presents information in approachable tables and summaries, focusing on high yield information useful for clinical consultation Is written by a team of experts and edited by recognized leaders in the field

This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.

Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation methods, novel in vitro systems including those employing stem cells, toxicogenomics and novel biomarkers. In each case, the most promising methods are discussed and compared to classical in vitro and in vivo toxicology assays. Finally, an outlook section discusses such forward-looking topics as immunotoxicology assessment and novel regulatory requirements. With its wealth of methodological knowledge and its critical evaluation of modern approaches, this is a valuable guide for toxicologists working in pharmaceutical development, as well as in safety assessment and the regulation of drugs and chemicals.

Microsurgery in Endodontics provides the definitive reference to endodontic microsurgery, with instructive photographs and illustrations. Provides a definitive reference work on endodontic microsurgery Includes contributions from pioneers and innovators in the field of microsurgical endodontics Describes techniques for a wide range of microsurgical procedures Includes more than 600 instructive illustrations and photographs

Featuring contributions from internationally recognized experts in point-of-care sonography, Emergency Point-of-Care Ultrasound, Second Edition combines a wealth of images with clear, succinct text to help beginners, as well as experienced sonographers, develop and refine their sonography skills. The book contains chapters devoted to scanning the chest, abdomen, head and neck, and extremities, as well as paediatric evaluations, ultrasound-guided vascular access, and more. An entire section is devoted to the syndromic approach for an array of symptoms and patient populations, including chest and abdominal pain, respiratory distress, HIV and TB coinfected patients, and pregnant patients. Also included is expert guidance on administering ultrasound in a variety of challenging environments, such as communities and regions with underdeveloped healthcare systems, hostile environments, and cyberspace. Each chapter begins with an introduction to the focused scan under discussion and a detailed description of methods for obtaining useful images. This is followed by examples of normal and abnormal scans, along with discussions of potential pitfalls of the technique, valuable insights from experienced users, and summaries of the most up-to-date evidence. Emergency Point-of-Care Ultrasound, Second Edition is a valuable working resource for emergency medicine residents and trainees, practitioners who are just bringing ultrasound scanning into their practices, and clinicians with many years of sonographic experience.

In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

Clostridial Diseases of Animals is the first book to focus on clostridial diseases in domestic and wild animals, offering a comprehensive reference on these common diseases. Provides a single resource for all aspects of clostridial diseases Presents current, comprehensive information with a focus on clinical relevance Covers each disease in depth, including etiology, epidemiology, clinics, gross pathology, histopathology, diagnostics, diagnostic criteria, prophylaxis, control, and treatment Written by the world-leading experts in the field of clostridial diseases in animals Offers photographs and summary tables to support the concepts discussed in the text and aid in recognition

Gynecologic and obstetric surgery is a craft that requires sound knowledge and skills. The specifics of each individual case must be understood to enable the best surgical management approach and to minimize complications. This resource book offers insightful management options to many of the challenges a gynecologic or obstetric surgeon may face before, during and after an operation. Divided into two sections, the book first covers general preoperative, intraoperative and postoperative challenges and, second, specific surgical procedures. It provides advice on both general gynecologic and obstetric operations, as well as subspecialist areas such as reproductive surgery, urogynecology and gynecologic oncology. The chapters are concise, beginning with illustrative case histories followed by background, management options, and any preventative approaches. Designed to guide the surgeon to safe practice throughout all stages, they offer practical and step-by-step help.

Using a case-based approach, Colorectal Surgery: Clinical Care and Management provides practical, clinical and expert guidance to illustrate the best care and clinical management of patients requiring colorectal surgery for colorectal disease. Real-life cases illustrate the entire syllabus of GI/colorectal surgery, being specially selected to highlight topical or controversial aspects of colorectal care. Cases have a consistent approach throughout and as well as outlining the actual management of each individual case, also offer an honest appraisal of the chosen management route, its successes and areas that could have been managed differently. Pedagogic features such as learning and decision points boxes aid rapid understanding/learning, enabling the reader to improve their patient management. In full colour and containing over 100 outstanding clinical photos and slides to support the cases, each section also covers recent developments/ landmark papers/ scoring systems and a thorough discussion of clinical management based on the major society guidelines from NICE, ASCRS and ECCO. Reliable, well-written and perfect for consultation in the clinical setting, Colorectal Surgery: Modern Clinical Care and Management is the perfect tool for all members of the multi-disciplinary team managing patients suffering from colorectal disease, specifically GI surgeons, gastroenterologists, oncologists and general surgeons.

Pancreatitis: medical and surgical management provides gastroenterologists and GI surgeons, both fully qualified and in training, with a focused, evidence-based approach to the most exciting developments in the diagnosis and clinical management of pancreatitis. Focusing mainly on the rapidly changing and innovative medical and surgical strategies to manage the disease, new surgical procedures such as endoscopic biliary intervention and minimally invasive necrosectomy to exciting new medical therapies like Antiprotease, Lexipafant, probiotics and enzyme treatment are all discussed. Full colour throughout, with over 250 colour illustrations and with reference to the latest clinical guidelines from the AGA, ACG and UEGW at all times, it is an essential consultation tool for all those managing patients with this increasingly common condition.