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Echocardiography Board Review, 2nd Edition 500 Multiple Choice Questions with Discussion Ramdas G. Pai, MD, Professor of Medicine, Loma Linda University, CA, USA Padmini Varadarajan, MD, Associate Professor of Medicine, Loma Linda University, CA, USA Echocardiography is an essential tool for the modern-day cardiologist and routinely used in the diagnosis, management and follow-up of patients with suspected or known heart diseases. This best-selling book now returns in a fully revised new edition, once again providing cardiologists and cardiology/echocardiography trainees with a rapid reference, self-assessment question and answer guide to all aspects of echocardiography. Packed with full-color images and written by experienced echocardiographers, the book covers: applied ultrasound physics practical hydrodynamics valvular heart disease myocardial diseases congenital heart disease non-invasive hemodynamics surgical echocardiography Containing 500 case-based questions, including clear explanations and discussions for every question, Echocardiography Board Review, 2nd Edition, is the perfect preparation guide for all those about to take the National Board of Echocardiography’s Board exam, including cardiology and echocardiography trainees and specialist physicians preparing for re-certification. Sonographers planning to take RDCS or RDMS certification examinations should find this book very helpful as well. Of related interest Practical Manual of Echocardiography in the Urgent Setting Fridman, ISBN 978-0-470-65997-7 Successful Accreditation in Echocardiography: A Self-Assessment Guide Banypersad, ISBN 978-0-470-65692-1 Website www.wiley.com/go/cardiology

Sichere und kontaminationsfreie Arzneimittel dank intelligenter Hygienekonzepte und Produktionsablaufe: Dieser neue Praxisleitfaden zu Grundlagen und Verfahren der hygienischen Pharmaproduktion deckt alle gangigen Arzneiformen ab. Von der Personalhygiene uber die Herstellungsverfahren der verschiedenen Arzneiformen (fest und flussig, steril und nicht-steril), von den verwendeten Medien und Hilfsstoffen bis hin zur Verpackung und zur Reinigung der Anlagen werden alle potenziellen Quellen von Kontaminationen unter Berucksichtigung der aktuellen Standards und Prufverfahren beschrieben und erklart. Fertigungsleiter und Qualitatsprufer in der betrieblichen Praxis sowie Sachverstandige in Pruf- und Regulierungsbehorden finden hier zahlreiche in der Praxis bewahrte Annleitungen zur Optimierung und Gewahrleistung einer hygienisch einwandfreien Produktion der unterschiedlichsten Arzneiformen.

The analysis of plants, insects, soil and other particulates from scenes of crime can be vital in proving or excluding contact between a suspect and a scene, targeting search areas, and establishing a time and place of death. Forensic Ecology: A Practitioner’s Guide provides a complete handbook covering all aspects of forensic ecology. Bringing together the forensic applications of anthropology, archaeology, entomology, palynology and sedimentology in one volume, this book provides an essential resource for practitioners in the field of forensic science, whether crime scene investigators, forensic science students or academics involved in the recovery and analysis of evidence from crime scenes. Forensic Ecology: A Practitioner’s Guide includes information not only on the search, location, recovery and analysis of evidence, but includes sampling strategies for diatom analysis, pollen and soils samples and entomology and provides guides for good practice. Each chapter provides background information on each discipline and is structured according to pre-scene attendance (what questions should the scientist ask when receiving a call? What sort of preparation is required?), scene attendance (including protocols at the scene, sampling strategies, recording), scientific examination of analysis of the evidence up to the stages and guidelines for witness statement and presenting evidence in court. The book is written by specialists in all fields with a wealth of experience who are current forensic practitioners around the world. It provides an essential and accessible resource for students, academics, forensic practitioners and police officers everywhere.

The relationship between infection and immunity and autophagy, a pathway of cellular homeostasis and stress response, has been a rapidly growing field of study over the last decade. While some cellular processes are pro- or anti-infection, autophagy has been proven to be both: a part of the innate immune response against some microbes, and a cellular pathway subverted by some pathogens to promote their own replication. Autophagy, Infection, and the Immune Response provides a unified overview of the roles of cellular autophagy during microbial infection. Introductory chapters ground the reader by delineating the autophagic pathway from a cellular perspective, and by listing assays available for measuring autophagy. Subsequent chapters address virus interactions with autophagy machinery, the various roles of autophagy parasitic infection, and interactions of bacteria with the autophagic pathway. Concluding chapters explore the relationships of autophagy to systemic immune responses, including antigen presentation, ER stress, and production of IFN-gamma. Designed as a resource for those interested in initiating studies on the relationship between autophagy and infection or immunity, Autophagy, Infection, and the Immune Response combines practical state-of the art technique descriptions with an overview of the wide variety of known interactions between pathogens and the autophagic pathway.

A comprehensive, quick-reference guide to the diagnosis and management of peripheral artery disease for non-specialists With an aging population subject to an increasing number of health risks, peripheral artery disease (PAD) is on the rise throughout the world. Because of PAD's direct links to heart attack and stroke, it is critical that internists, surgeons, cardiologists, radiologists, gerontologists, GPs, and family practitioners know how to recognize it and make the best treatment recommendations for their patients. This book provides all the expert, practical information and guidance they need to do just that. Edited by two thought leaders in PAD diagnosis and treatment, and comprising chapters written by subject matter experts, Peripheral Artery Disease, Second Edition provides clinicians with guidance on how to diagnose and treat one of the most under-diagnosed conditions affecting millions of patients. This updated and revised edition of the popular guide distills the complexities of PAD into clear, actionable advice for busy medical practitioners, providing them with the information they need—when they need it. Provides clinicians with essential information for recognizing and treating this under-diagnosed condition that affects millions of patients Distills the complexities of PAD, from diagnosis to traditional and emerging treatment options, into clear, actionable advice for clinicians Covers PAD epidemiology, office examination, imaging, laboratory evaluation, medical therapy, surgical interventions, endovascular treatments, and much more Reflects the latest PAD Guidelines and Performance Measures established by leading specialty societies Features contributions from internists and surgeons, all recognized experts in PAD Peripheral Artery Disease, Second Edition is an important working reference for internists, cardiologists, radiologists, and surgeons, as well as fellows and residents in those fields.

Exposure to chronic stress has cumulative adverse effects on physical and mental health, considered to be the consequence of chronic exposure to high levels of stress hormones. Consequently, there is extensive research in progress to investigate and better understand how the brain organises neuroendocrine stress responses and how interventions may be able to moderate these responses to improve mental and physical health. Neuroendocrinology of Stress highlights current knowledge of the organisation and physiology of these stress response systems, how the impact of dysregulation of these systems is being investigated, and considers the ways in which contributions to both psychiatric and physical diseases resulting from chronic stress effects can be critically addressed in basic research Written by a team of internationally renowned researchers, each chapter presents a succinct summary of the very latest developments in the field Both print and enhanced e-book versions are available Illustrated in full colour throughout This is the second volume in a new Series «Masterclass in Neuroendocrinology», a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA

Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. Reviews of the latest advances in our understanding of the neurobiological basis of migraine Translates important research findings from around the globe into novel treatments strategies currently being investigated Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications Includes contributions by many of the most respected researchers in the field, world-wide Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches.

Clinical Anatomy of the Eye has proved to be a very popular textbook for ophthalmologists and optometrists in training all over the world. The objective of the book is to provide the reader with the basic knowledge of anatomy necessary to practice ophthalmology. It is recognised that this medical speciality requires a detailed knowledge of the eyeball and the surrounding structures. The specialist's knowledge should include not only gross anatomic features and their development, but also the microscopic anatomy of the eyeball and the ocular appendages. The nerve and blood supply to the orbit, the autonomic innervation of the orbital structures, the visual pathway, and associated visual reflexes should receive great emphasis. The practical application of anatomic facts to ophthalmology has been emphasised throughout this book in the form of Clinical Notes in each chapter. Clinical problems requiring anatomic knowledge for their solution are presented at the end of each chapter. Illustrations are kept simple and overview drawings of the distribution of the cranial and autonomic nerves have been included.

Errors in Veterinary Anesthesia is the first book to offer a candid examination of what can go wrong when anesthetizing veterinary patients and to discuss how we can learn from mistakes. Discusses the origins of errors and how to learn from mistakes Covers common mistakes in veterinary anesthesia Provides strategies for avoiding errors in anesthetizing small and large animal patients Offers tips and tricks to implement in clinical practice Presents actual case studies discussing errors in veterinary anesthesia

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

Tested and proven solutions to the challenges of biological drug product development Biological drug products play a central role in combating human diseases; however, developing new successful biological drugs presents many challenges, including labor intensive production processes, tighter regulatory controls, and increased market competition. This book reviews the current state of the science, offering readers a single resource that sets forth the fundamentals as well as tested and proven development strategies for biological drugs. Moreover, the book prepares readers for the challenges that typically arise during drug development, offering straightforward solutions to improve their ability to pass through all the regulatory hurdles and deliver new drug products to the market. Biological Drug Products begins with general considerations for the development of any biological drug product and then explores the strategies and challenges involved in the development of specific types of biologics. Divided into five parts, the book examines: Part 1: General Aspects Part 2: Proteins and Peptides Part 3: Vaccines Part 4: Novel Biologics Part 5: Product Administration/Delivery Each chapter has been prepared by one or more leading experts in biological drug development. Contributions are based on a comprehensive review and analysis of the current literature as well as the authors' first-hand experience developing and testing new drugs. References at the end of each chapter serve as a gateway to original research papers and reviews in the field. By incorporating lessons learned and future directions for research, Biological Drug Products enables pharmaceutical scientists and students to improve their success rate in developing new biologics to treat a broad range of human diseases.

A thoroughly updated edition of this essential reference guide for physiotherapists and physical therapists, looking to apply the proven benefits of physiotherapy to the treatment of companion and performance animals. Seven new chapters provide greatly expanded coverage of practical treatment and rehabilitation Includes reviews of different physiotherapy techniques, drawing on both human and animal literature Discusses approaches in small animal medicine as well as for elite equine athletes Provides applied evidence-based clinical reasoning model, with case examples Now in full colour with many more illustrations