Медицина - скачать книги или читать онлайн. Страница 134

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Color Atlas of Equine Pathology offers a practical guide to identifying equine diseases, presenting a single resource with more than 1000 images showing predominantly gross pathology. Organized by body systems, the book allows for picture matching during or after an equine necropsy. In this user-friendly atlas, each chapter takes a common format, presenting the disease process as well as congenital, degenerative, inflammatory, and neoplastic sequences, with text boxes offering quick reference to key information. The book begins with an introductory chapter summarizing the principles of the equine field necropsy, and subsequent organ-based chapters depict gross features of disease, focusing on macroscopic digital images supplemented by histology and immunohistochemistry when necessary. Some clinical information for correlation with pathology is included. Color Atlas of Equine Pathology is an essential resource for diagnostic veterinary pathologists and pathology residents, as well as for equine practitioners performing necropsies in the field.

Clinical Skills for Healthcare Assistants and Assistant Practitioners is an accessible, easy-to-read guide, outlining the fundamental and core skills integral to clinical practice. Fully updated in its second edition, this book is divided into three sections; the first looks at fundamental skills applicable to all staff, such as accountability, communication and record keeping. Section two explores core clinical skills such as respiratory care, pulse, blood glucose management and catheter care. Section three outlines complex clinical skills that require more in-depth training, such as medication and intravenous cannulation. An invaluable resource for healthcare assistants and assistant practitioners, this book will also be of use to newly qualified practitioners, and students in health and social care.

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Gastroenterologists require detailed knowledge regarding the anatomy of the GI system in order to understand the disturbances caused by diseases they diagnose and treat. Gastrointestinal Anatomy and Physiology will bring together the world’s leading names to present a comprehensive overview of the anatomical and physiological features of the gastrointestinal tract. Full colour and with excellent anatomical and clinical figures throughout, it will provide succinct, authoritative and didactic anatomic and physiologic information on all the key areas, including GI motility, hepatic structure, GI hormones, gastric secretion and absorption of nutrients. GI trainees will enjoy the self-assessment MCQs, written to the level they will encounter during their Board exams, and the seasoned gastroenterologist will value it as a handy reference book and refresher for re-certification exams

This book is a comprehensive guide to the essential areas of health care human resources management, and is an immediately useful practical handbook for practitioners as well as a textbook for use health care management programs. Written by the authors of Handbook for the New Health Care Manager and Human Resources Management for Public and Nonprofit Organizations, the book covers the context of human resources management in the unique health care business arena from a strategic perspective includes SHRM and human resources planning, organizational culture and assessment, and the legal environment of human resources management. Managing volunteers and job analysis perfor­mance appraisal instruments, training and development programs, and recruitment, targeted selection and hiring techniques are covered. Compensation poli­cies and practices, employer-provided benefits management, implementation of training and organizational development programs, as well as labor-management relations for health care organizations and healthcare human resource information technology are covered, with practical examples and proven strategies amply provided in each chapter.

Providing an overview of the formative years of a junior doctor’s career, The Foundation Programme at a Glance consolidates the generic and condition-specific skills required to excel in this stage of training. Taking a simple and holistic approach to providing support for junior doctors, it integrates text and image content to suit all learning styles. Sections include advice on making the most of your training, tips on good clinical practice, communication, and common presentations and conditions. Edited by the National Director and Deputy National Director of the UK Foundation Programme, each section is written by experts in their respective fields, presenting insights into the programme with unrivalled authority. The Foundation Programme at a Glance: • Uses diagrams, line drawings and flow charts to clearly illustrate concepts • Follows the current Foundation Programme curriculum • Integrates theory and practice This comprehensive and practical volume contains all the vital information you need to reach excellence during the foundation years, and to get the most out of your time on the programme.

Canine and Feline Behavior for Veterinary Technicians and Nurses provides the veterinary technician with a solid foundation in behavioral medicine. Designed as a daily resource for interacting with and educating pet owners, the book familiarizes readers with the behavioral, mental, and emotional needs of dogs and cats. Canine and Feline Behavior for Veterinary Technicians and Nurses offers a complete guide to the technician’s role in behavioral preventive services and how to assist the veterinarian with behavioral intervention. Covering the roles of animal behavior professionals, normal development of dogs and cats, and the human-animal bond, the book includes correlations from human mental health care throughout. The book encompasses learning theory, preventive behavioral services, standardized behavior modification terms and techniques, and veterinary behavior pharmacology. Canine and Feline Behavior for Veterinary Technicians and Nurses is an essential resource for veterinary technicians to realize their full potential and become a pivotal component of the behavioral health care team for canine and feline patients.

The assessment of patient reported outcomes and health-related quality of life continue to be rapidly evolving areas of research and this new edition reflects the development within the field from an emerging subject to one that is an essential part of the assessment of clinical trials and other clinical studies. The analysis and interpretation of quality-of-life assessments relies on a variety of psychometric and statistical methods which are explained in this book in a non-technical way. The result is a practical guide that covers a wide range of methods and emphasizes the use of simple techniques that are illustrated with numerous examples, with extensive chapters covering qualitative and quantitative methods and the impact of guidelines. The material in this new third edition reflects current teaching methods and content widened to address continuing developments in item response theory, computer adaptive testing, analyses with missing data, analysis of ordinal data, systematic reviews and meta-analysis. This book is aimed at everyone involved in quality-of-life research and is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and clinical practice.

Musculoskeletal X-rays for Medical Students provides the key principles and skills needed for the assessment of normal and abnormal musculoskeletal radiographs. With a focus on concise information and clear visual presentation, it uses a unique colour overlay system to clearly present abnormalities. Musculoskeletal X-rays for Medical Students: • Presents each radiograph twice, side by side – once as would be seen in a clinical setting and again with clearly highlighted anatomy or pathology • Focuses on radiographic appearances and abnormalities seen in common clinical presentations, highlighting key learning points relevant to each condition • Covers introductory principles, normal anatomy and common pathologies, in addition to disease-specific sections covering adult and paediatric practice • Includes self-assessment to test knowledge and presentation techniques Musculoskeletal X-rays for Medical Students is designed for medical students, junior doctors, nurses and radiographers, and is ideal for both study and clinical reference.

The must-have statistics guide for students of health services Statistics for Health Care Management and Administration is a unique and invaluable resource for students of health care administration and public health. The book introduces students to statistics within the context of health care, focusing on the major data and analysis techniques used in the field. All hands-on instruction makes use of Excel, the most common spreadsheet software that is ubiquitous in the workplace. This new third edition has been completely retooled, with new content on proportions, ANOVA, linear regression, chi-squares, and more, Step-by-step instructions in the latest version of Excel and numerous annotated screen shots make examples easy to follow and understand. Familiarity with statistical methods is essential for health services professionals and researchers, who must understand how to acquire, handle, and analyze data. This book not only helps students develop the necessary data analysis skills, but it also boosts familiarity with important software that employers will be looking for. Learn the basics of statistics in the context of Excel Understand how to acquire data and display it for analysis Master various tests including probability, regression, and more Turn test results into usable information with proper analysis Statistics for Health Care Management and Administration gets students off to a great start by introducing statistics in the workplace context from the very beginning.

The Reproductive System at a Glance is a comprehensive guide to normal reproductive biology and associated pathophysiology in both sexes. Concise, easy to read, and clearly structured, the double-page spreads progress from basic science to clinical abnormalities, and covers endocrine production and action, within one short volume. Chapters on disorders summarise epidemiology, pathophysiology, diagnosis and treatment. This new edition of The Reproductive System at a Glance: • Is fully revised and updated throughout to reflect recent developments in practice • Now features histological and pathological slides to complement the “at a glance” style explanatory illustrations • Now features radiologic studies to supplement the text in selected chapters • Contains more detailed coverage of maternal adaptations to pregnancy • Includes a companion website at www.ataglanceseries.com/reproduction featuring self-assessment multiple choice questions, bonus single answer questions and flashcards The Reproductive System at a Glance is an ideal guide for students studying both endocrine and reproductive subjects, and teaches the foundation concepts for the obstetrics and gynaecology rotation, helping health professionals and students achieve a broad and practical understanding of the topic.