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This bestseller has been an essential book for all those working with laboratory animals since it was first published in 1994. This fourth edition retains all the classic features that have made it a must-have reference including emphasis on best practice in order to improve animal welfare. The contents have been thoroughly updated and reorganised to make sure it is a really practical book for day-to-day use in the laboratory. The first section of the book covers principles applicable to all species, for example husbandry, handling and the education and training required by scientists and technical staff working with animals in the laboratory. Later chapters focus on specific species or groups of species. New to this edition: • Reflects changes in European legislation and their impact on national legislation • Covers recommendations for the education and training of those carrying out animal experiments across Europe • New chapters on ethical considerations and balancing animal welfare with science • New information on environmental enrichment for laboratory animals • Covers advancements in anaesthesia and analgesia and techniques • Spiral bound for ease-of-use as a bench-top reference This book is ideal for all personnel carrying out scientific procedures using animals, particularly during training and also for the new researcher. It will also be essential reading for study directors designing research programmes, animal technicians and veterinarians working with laboratory animal species.

As haemophilia is a life-long condition, continuing supervision by a group of medical personnel is required. In many countries this is provided by comprehensive care haemophilia centres where staff of all specialities concerned with treatment- haematologists, paediatricians, nurses, physiotherapists, orthopaedic surgeons – have specialized knowledge. This new book is a definitive resource on the current aspects and issues around haemophilia. Complications of haemophilia care are well covered in chapters on inhibitors, and musculoskeletal problems, as are all the latest developments in the field of haemophilia.

Infectious disease surveillance has evolved at an extraordinary pace during the past several decades, and continues to do so. It is increasingly used to inform public health practice in addition to its use as a tool for early detection of epidemics. It is therefore crucial that students of public health and epidemiology have a sound understanding of the concepts and principles that underpin modern surveillance of infectious disease. Written by leaders in the field, who have vast hands-on experience in conducting surveillance and teaching applied public health, Concepts and Methods in Infectious Disease Surveillance is comprised of four sections. The first section provides an overview, a description of systems used by public health jurisdictions in the United States and legal considerations for surveillance. The second section presents chapters on major program-area or disease-specific surveillance systems, including those that monitor bacterial infections, foodborne diseases, healthcare-associated infections, and HIV/AIDS. The following section is devoted to methods for conducting surveillance and also approaches for data analysis. A concluding section summarizes communication of surveillance findings, including the use of traditional and social media, in addition to showcasing lessons learned from the New York City Department of Health’s experience in surveillance and epidemiology training. This comprehensive new book covers major topics at an introductory to intermediate level, and will be an excellent resource for instructors. Suitable for use in graduate level courses in public health, human and veterinary medicine, and in undergraduate programs in public-health-oriented disciplines, Concepts and Methods in Infectious Disease Surveillance is also a useful primer for frontline public health practitioners, hospital epidemiologists, infection control practitioners, laboratorians in public health settings, infectious disease researchers, and medical and public health informaticians interested in a concise overview of infectious disease surveillance.

Like having a trusted clinician with you in the exam room, the fully updated Sixth Edition of Blackwell's Five-Minute Veterinary Consult: Canine and Feline continues to offer fast access to information in an easy-to-use format. Provides fast access to key information on the diagnosis and treatment of diseases and conditions in dogs and cats Covers 846 specific disorders, making it the most comprehensive quick-reference book on canine and feline medicine Carefully designed for fast searching and reference in the busy practice setting, giving you the confidence to make clinical decisions quickly and appropriately Presents contributions from 379 leading experts specializing in all areas of veterinary medicine Includes access to a companion website with 354 client education handouts for you to download and use in practice, plus images and video clips

Now in its Fifth Edition, Functional Anatomy and Physiology of Domestic Animals provides a basic understanding of domestic animal anatomy and physiology, taking an interconnected approach to structure and function of the horse, dog, cat, cow, sheep, goat, pig, and chicken. Offers a readable introduction to basic knowledge in domestic animal anatomy and physiology Covers equine, canine, feline, bovine, ovine, ruminant, swine, and poultry anatomy and physiology Considers structure and function in relation to each other for a full understanding of the relationship between the two Provides pedagogical tools to promote learning, including chapter outlines, study questions, self-evaluation exercises, clinical correlates, key terms, suggested readings, and a robust art program Includes access to a companion website with video clips, review questions, and the figures from the book in PowerPoint

"Chronic total occlusions continue to represent one of the greatest challenges to interventional cardiologists." – Cardiovascular Research Foundation – Chronic Total Occlusions or CTOs can be found in 30% of patients with coronary artery disease. Despite advances, CTOs remain one of the most frequently identified lesions in interventional cardiology yet least likely to be successfully treated. The prevalence of the disorder is vexing. The threat to your patients is significant. The condition is complex. And, treatment remains a challenge. Learn how to approach CTOs from internationally-recognized physician-educators Turn to Chronic Total Occlusions: A Guide to Recanalization, 2e for expert insight into the world of CTOs and clear, practical guidance you can apply directly and immediately in your cath lab. Offering the most comprehensive information available, this completely updated second edition provides you wih: Full-color images from the diagnostic modalities that are essential in identifying CTOs Data on indications and efficacy from the most recent clinical trials Practical guidance on the selection and use of the latest wires and devices Even more tips and tricks from leading operators from the world’s busiest centers Clinical cases to illustrate some of the more complex scenarios and common complications And more! Chronic Total Occlusions: A Guide to Recanalization, 2e is the guide you can count on to improve the CTO success rate at your facility. Order your copy today!

Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field.

Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.

The ADA Practical Guide to Soft Tissue Oral Disease is the perfect tool to aid in identifying, diagnosing and treating soft tissue oral disease in everyday clinical practice. Focusing on the clinical aspects of management required by the general dental team, this book expertly guides readers through screening examinations, description and documentation, differential diagnosis, and guidelines for observation and referral. Ideal as a clinical handbook or review guide, The ADA Practical Guide to Soft Tissue Oral Disease is replete with color photos, case studies and discussion, and synopses of best current treatments based on up-to-date literature. Section 1 includes basic information of how to most effectively and efficiently perform a complete and thorough head and neck soft tissue screening examination. Section 2 presents an overview of the top 40 oral soft tissue lesions, as well as several less common but life-threatening conditions such as oral cancer and infections. Section 3 is composed of a series of brief patient clinical scenarios with diagnostic exercises for self-test and evaluation by providing discussion of the correct diagnosis and distractors.

Male Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia provides urologists of all levels with a practical, highly clinical guide to the variety of different symptoms and problems concerning the male lower urinary tract, including benign prostatic hyperplasia, one of the conditions that urologists most regularly encounter. Evidence-based throughout and written by the world's leading experts in the topic, it comprehensively reviews the very latest in diagnostics and imaging, patient phenotyping, genetic studies, medical and surgical therapies, and lifestyle management in order to help clinicians best manage their patients. Highlights include chapters on: Alpha-Adrenergic Antagonists for Lower Urinary Symptoms Secondary to Benign Prostatic Hyperplasia Phosphodiesterase Type 5 inhibitors for Male LUTS Combination Medical Therapy for Male LUTS Open Simple Prostatectomy Minimally Invasive Therapies Monopolar and Bipolar Transurethral Resection of the Prostate GreenLight Laser Therapy Containing pitfall boxes and key points throughout to aid quick and easy understanding of the key information, this excellent book is an essential read for the modern-day urologist.

Digital Planning and Custom Orthodontic Treatment offers a thorough overview of digital treatment planning as it relates to custom orthodontic treatment. Covers 3D imaging of the dentition and the face with intraoral scanners, CBCT machines, and 3D facial scanners Provides a complete guide to using digital treatment planning to improve the predictability, efficiency, and efficacy of orthodontic treatment Discusses CAD/CAM fabrication of appliances and the monitoring of treatment progress and stability Offers detailed descriptions for the main commercial systems on the market Presents clinically oriented information to aid in yielding high quality and stable results

In the post-Daubert era, forensic science disciplines are increasingly informed by robust, statistically-sound experimental research. The educational value of the well-documented case study, however, remains as important as ever. Emphasizing known contextual information, this volume serves as a case-driven guide to skeletal trauma analysis through the unique perspective of each chapter’s authors. Both forensic anthropologists and pathologists contribute skeletal trauma cases covering a range of topics including child abuse, blunt force trauma, descents from height, plane crashes, sharp force trauma and dismemberment, gunshot wounds, blast trauma, and burned body interpretation. Several chapters also include a discussion of potentially confounding taphonomic influences such as animal scavenging, water immersion, burning, and extended postmortem intervals. Detailed descriptions with multiple supporting images allow the practitioner’s skeletal trauma interpretation to be compared to the “answer” as it pertains to the known circumstances surrounding the traumatic events of each case.